Firing Dynamics and Modulatory Actions of Supraspinal Dopaminergic Neurons during Zebrafish Locomotor Behavior
Identifieur interne : 000036 ( Main/Exploration ); précédent : 000035; suivant : 000037Firing Dynamics and Modulatory Actions of Supraspinal Dopaminergic Neurons during Zebrafish Locomotor Behavior
Auteurs : Michael Jay [Royaume-Uni] ; Francesca De Faveri [Royaume-Uni] ; Jonathan Robert Mcdearmid [Royaume-Uni]Source :
- Current Biology [ 0960-9822 ] ; 2015.
Abstract
Dopamine (DA) has long been known to have modulatory effects on vertebrate motor circuits. However, the types of information encoded by supraspinal DAergic neurons and their relationship to motor behavior remain unknown.
By conducting electrophysiological recordings from awake, paralyzed zebrafish larvae that can produce behaviorally relevant activity patterns, we show that supraspinal DAergic neurons generate two forms of output: tonic spiking and phasic bursting. Using paired supraspinal DA neuron and motoneuron recordings, we further show that these firing modes are associated with specific behavioral states. Tonic spiking is prevalent during periods of inactivity while bursting strongly correlates with locomotor output. Targeted laser ablation of supraspinal DA neurons reduces motor episode frequency without affecting basic parameters of motor output, strongly suggesting that these cells regulate spinal network excitability.
Our findings reveal how vertebrate motor circuit flexibility is temporally controlled by supraspinal DAergic pathways and provide important insights into the functional significance of this evolutionarily conserved cell population.
Url:
DOI: 10.1016/j.cub.2014.12.033
PubMed: 25639243
PubMed Central: 4331284
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Firing Dynamics and Modulatory Actions of Supraspinal Dopaminergic Neurons during Zebrafish Locomotor Behavior</title><author><name sortKey="Jay, Michael" sort="Jay, Michael" uniqKey="Jay M" first="Michael" last="Jay">Michael Jay</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH</wicri:regionArea></affiliation></author><author><name sortKey="De Faveri, Francesca" sort="De Faveri, Francesca" uniqKey="De Faveri F" first="Francesca" last="De Faveri">Francesca De Faveri</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH</wicri:regionArea></affiliation></author><author><name sortKey="Mcdearmid, Jonathan Robert" sort="Mcdearmid, Jonathan Robert" uniqKey="Mcdearmid J" first="Jonathan Robert" last="Mcdearmid">Jonathan Robert Mcdearmid</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25639243</idno><idno 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type="wicri:Area/Main/Exploration">000036</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Firing Dynamics and Modulatory Actions of Supraspinal Dopaminergic Neurons during Zebrafish Locomotor Behavior</title><author><name sortKey="Jay, Michael" sort="Jay, Michael" uniqKey="Jay M" first="Michael" last="Jay">Michael Jay</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH</wicri:regionArea></affiliation></author><author><name sortKey="De Faveri, Francesca" sort="De Faveri, Francesca" uniqKey="De Faveri F" first="Francesca" last="De Faveri">Francesca De Faveri</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH</wicri:regionArea></affiliation></author><author><name sortKey="Mcdearmid, Jonathan Robert" sort="Mcdearmid, Jonathan Robert" uniqKey="Mcdearmid J" first="Jonathan Robert" last="Mcdearmid">Jonathan Robert Mcdearmid</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester LE1 7RH</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current Biology</title><idno type="ISSN">0960-9822</idno><idno type="eISSN">1879-0445</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Background</title><p>Dopamine (DA) has long been known to have modulatory effects on vertebrate motor circuits. However, the types of information encoded by supraspinal DAergic neurons and their relationship to motor behavior remain unknown.</p></sec><sec><title>Results</title><p>By conducting electrophysiological recordings from awake, paralyzed zebrafish larvae that can produce behaviorally relevant activity patterns, we show that supraspinal DAergic neurons generate two forms of output: tonic spiking and phasic bursting. Using paired supraspinal DA neuron and motoneuron recordings, we further show that these firing modes are associated with specific behavioral states. Tonic spiking is prevalent during periods of inactivity while bursting strongly correlates with locomotor output. Targeted laser ablation of supraspinal DA neurons reduces motor episode frequency without affecting basic parameters of motor output, strongly suggesting that these cells regulate spinal network excitability.</p></sec><sec><title>Conclusions</title><p>Our findings reveal how vertebrate motor circuit flexibility is temporally controlled by supraspinal DAergic pathways and provide important insights into the functional significance of this evolutionarily conserved cell population.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Garraway, S M" uniqKey="Garraway S">S.M. Garraway</name></author><author><name sortKey="Hochman, S" uniqKey="Hochman S">S. Hochman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemens, S" uniqKey="Clemens S">S. Clemens</name></author><author><name sortKey="Hochman, S" uniqKey="Hochman S">S. 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Rihel</name></author><author><name sortKey="Onah, A A" uniqKey="Onah A">A.A. Onah</name></author><author><name sortKey="Sung, R J" uniqKey="Sung R">R.J. Sung</name></author><author><name sortKey="Schier, A F" uniqKey="Schier A">A.F. Schier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaslin, J" uniqKey="Kaslin J">J. Kaslin</name></author><author><name sortKey="Nystedt, J M" uniqKey="Nystedt J">J.M. Nystedt</name></author><author><name sortKey="Osterg Rd, M" uniqKey="Osterg Rd M">M. Ostergård</name></author><author><name sortKey="Peitsaro, N" uniqKey="Peitsaro N">N. Peitsaro</name></author><author><name sortKey="Panula, P" uniqKey="Panula P">P. Panula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feitl, K E" uniqKey="Feitl K">K.E. Feitl</name></author><author><name sortKey="Ngo, V" uniqKey="Ngo V">V. Ngo</name></author><author><name sortKey="Mchenry, M J" uniqKey="Mchenry M">M.J. McHenry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flock, A" uniqKey="Flock A">A. Flock</name></author><author><name sortKey="Russell, I J" uniqKey="Russell I">I.J. Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, I J" uniqKey="Russell I">I.J. Russell</name></author><author><name sortKey="Roberts, B L" uniqKey="Roberts B">B.L. Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westerfield, M" uniqKey="Westerfield M">M. Westerfield</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Jay, Michael" sort="Jay, Michael" uniqKey="Jay M" first="Michael" last="Jay">Michael Jay</name></noRegion><name sortKey="De Faveri, Francesca" sort="De Faveri, Francesca" uniqKey="De Faveri F" first="Francesca" last="De Faveri">Francesca De Faveri</name><name sortKey="Mcdearmid, Jonathan Robert" sort="Mcdearmid, Jonathan Robert" uniqKey="Mcdearmid J" first="Jonathan Robert" last="Mcdearmid">Jonathan Robert Mcdearmid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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